Cytotoxicity, Antimicrobial, Antioxidant, Anthelmintic, and Anti-Inflammatory Activities and FTIR Analysis of Combretum nioroense Stem Bark

Combretum nioroense is widely used in the folkloric treatment of a variety bacterial and helminthic infections. The decoction its leaves traditionally fed to newborn babies some rural parts Ghana. study focused on identifying prime components petroleum ether ethanolic extracts stem bark using standard phytochemical screening protocols chromatographic spectroscopic techniques. activities (cytotoxicity, antimicrobial, antioxidant, anthelmintic, anti-inflammatory) C. were also investigated. Preliminary analysis revealed presence glycosides, saponins, phenols, coumarins, alkaloids, flavonoids, tannins, steroids, phytosterols, flavanols, terpenoids, cardiac glycosides. action Milsonia ghanensis worms was concentration-dependent, with least concentration (0.75 mg/mL) paralyzing killing M. after maximal exposure time. IC50 values for ethanol DPPH assay >100.0 27.940 ± 1.005 μg/mL those H2O2 400.900 3.400 322.500 μg/mL, respectively. total antioxidant capacities (TACs) 47.197 0.533 57.968 0.560 gAAE/100 g, value extract cytotoxicity studies 115.4 1.332 μg/mL. MICs against test organisms within range 0.0122–25.0 mg/mL. (petroleum ethanol) showed concentration-dependent increase anti-inflammatory activity 31.254 0.359 24.402 0.569 Chromatographic separations gave three fractions. FTIR purified fractions functional groups, confirming phytochemicals identified test. results indicate that both exhibit cytotoxicity, activities, thereby proving use treat ailments caused by microorganisms.